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Article

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking.

Communications biology - 8 Feb 2022

Dey Debajit, Singh Suruchi, Khan Saif, Martin Matthew, Schnicker Nicholas J, Gakhar Lokesh, Pierce Brian G, Hasan S Saif

Abstract excerpt

β-Coronaviruses such as SARS-CoV-2 hijack coatomer protein-I (COPI) for spike protein retrograde trafficking to the progeny assembly site in endoplasmic reticulum-Golgi intermediate compartment (ERGIC). However, limited residue-level details are available into how the spike interacts with COPI. Here we identify an extended COPI binding motif in the spike that encompasses the canonical K-x-H dibasic sequence. This...

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Identifiers

PMID: 35136165
DOI: 10.1038/s42003-022-03063-y
PMCID: PMC8825798

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