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Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

3 Jul 2024

Abstract excerpt

The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor tropism remain elusive. We designed an active human TMPRSS2 construct enabling high-yield recombinant production in human cells of this key therapeutic target. We determined a...

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PMID: 38964328
DOI: 10.1016/j.cell.2024.06.006

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