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SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains

16 Oct 2024

Abstract excerpt

Increasing evidence suggests that mutations in the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may enhance viral replication by modulating the assembly process. However, the mechanisms governing the selective packaging of viral genomic RNA by the N protein, along with the assembly and budding processes, remain poorly understood. Utilizing a virus-like particles (VLPs)...

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PMID: 39412257
DOI: 10.1128/jvi.01036-24

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