The Glucose Transporter 5 Enhances CAR-T Cell Metabolic Function and Anti-tumour Durability

Abstract excerpt

<title>Abstract</title> <p>Activated T cells undergo a metabolic shift to aerobic glycolysis to support the energetic demands of proliferation, differentiation, and cytolytic function. Transmembrane glucose flux is facilitated by glucose transporters (GLUT) that play a vital role in T cell metabolic reprogramming and anti-tumour function. GLUT isoforms are regulated at the level of expression and subcellular dist...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cancer-related Molecular Pathways
• CAR-T cell therapy research
• Diet, Metabolism, and Disease
• Disease Progression
• Immune Cell Function and Interaction
• Metabolism, Diabetes, and Cancer
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

a74ad1b2-ca2c-51d7-bb85-a1a71646d7e7

DOI

10.21203/rs.3.rs-4342820/v1