Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

1 Feb 2020

Abstract excerpt

As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Immune cells in cancer
Share to Sphingolipid Metabolism and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32024090
DOI: 10.3390/cells9020337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer HallmarksPMID 32024090Read ↗

Targeting the Sphingolipid Rheostat in GliomasSemantic proximity Read ↗

Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindranceSemantic proximity Read ↗

The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistanceSemantic proximity Read ↗

Implication of Ceramide Kinase/C1P in Cancer Development and ProgressionSemantic proximity Read ↗

Glioma: molecular signature and crossroads with tumor microenvironmentSemantic proximity Read ↗

Extracellular Sphingosine-1-Phosphate: A Novel Actor in Human Glioblastoma Stem Cell SurvivalSemantic proximity Read ↗

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal CancerSemantic proximity Read ↗

<i>SMPD3</i> suppresses IDH mutant tumor growth via dual autocrine-paracrine rolesSemantic proximity Read ↗

Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerabilitySemantic proximity Read ↗

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging TargetSemantic proximity Read ↗

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem CellsSemantic proximity Read ↗

mTOR signaling in glioblastoma: lessons learned from bench to bedsideSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.