Article
Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females.
Genetics - 1 Apr 2007
Feitsma Harma, Leal Marcelo C, Moens Peter B, Cuppen Edwin, Schulz Rüdiger W
Abstract excerpt
In most eukaryotes, recombination of homologous chromosomes during meiosis is necessary for proper chromosome pairing and subsequent segregation. The molecular mechanisms of meiosis are still relatively unknown, but numerous genes are known to be involved, among which are many mismatch repair genes. One of them, mlh1, colocalizes with presumptive sites of crossing over, but its exact action remains unclear. We...
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