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SAAMBE-MEM: a sequence-based method for predicting binding free energy change upon mutation in membrane protein-protein complexes.

Bioinformatics (Oxford, England) - 2 Sept 2024

Rimal Prawin, Panday Shailesh Kumar, Xu Wang, Peng Yunhui, Alexov Emil

Abstract excerpt

MOTIVATION: Mutations in protein-protein interactions can affect the corresponding complexes, impacting function and potentially leading to disease. Given the abundance of membrane proteins, it is crucial to assess the impact of mutations on the binding affinity of these proteins. Although several methods exist to predict the binding free energy change due to mutations in protein-protein complexes, most require...

Topics

Membrane Proteins
Databases, Protein
Mutation
Protein Binding
Machine Learning
Algorithms
Thermodynamics
Computational Biology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39240325
DOI: 10.1093/bioinformatics/btae544
PMCID: PMC11407696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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