Exploring the interplay between experimental methods and the performance of predictors of binding affinity change upon mutations in protein complexes.

Abstract excerpt

Reliable prediction of binding affinity changes (ΔΔG) upon mutations in protein complexes relies not only on the performance of computational methods but also on the availability and quality of experimental data. Binding affinity changes can be measured by various experimental methods with different accuracies and limitations. To understand the impact of these on the prediction of binding affinity change, we...

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