Article

CRISPR/Cas9-mediated microRNA-21 Cleavage Sensitizes the Treatment Response to Dasatinib in Chronic Myeloid Leukemia Cell Line K562

2020-03-31

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<title>Abstract</title> <p>Background: Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 kinase are effective in treating chronic myeloid leukemia (CML), but TKI resistance occurs in a significant number of patients, and the underlying molecular mechanisms of this resistance remain largely unknown. As an oncomiR, microRNA-21(miR-21) functions directly in drug resistance, but its relationship with TKI resistanc...

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Literature Corpus work: a6c7dfe7-1376-5471-8a13-0b7a1fad0862
DOI: 10.21203/rs.3.rs-20046/v1

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