Article
Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system.
International journal of hematology - 1 Oct 2022
Nguyen Thao T T, Tamai Minori, Harama Daisuke, Kagami Keiko, Kasai Shin, Watanabe Atsushi, Akahane Koshi, Goi Kumiko, Inukai Takeshi
Abstract excerpt
Imatinib and second-generation tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, overcoming TKI resistance due to the T315I gatekeeper mutation of BCR/ABL1 is crucial for further improving the prognosis. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is appropriate...
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