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CRISPR/Cas9-directed Gene Trap Constitutes a Selection System for Corrected BCR/ABL Leukemic Cells in CML

2022-05-04

Abstract excerpt

Chronic myeloid leukaemia (CML) is a haematological neoplasm driven by the BCR/ABL fusion oncogene. The monogenic aspect of the disease and the feasibility of ex vivo therapies in haematological disorders make CML an excellent candidate for gene therapy strategies. The ability to abolish any coding sequence by CRISPR-Cas9 nucleases offers a powerful therapeutic opportunity to CML patients. However, a definitive cu...

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Literature Corpus work
c996a047-a6d2-500d-85ab-9ca48eb72914
DOI
10.20944/preprints202205.0008.v1
Open publication

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