Article

upsAI: A high-accuracy machine learning classifier for predicting <i>Plasmodium falciparum var</i> gene upstream groups

2025-05-23

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 ( Pf EMP1), encoded by the hypervariable var gene family, is central to malaria pathogenesis, influencing both disease severity and immune evasion. Classifying var genes into upstream groups (upsA, upsB, upsC, upsE) is important for understanding parasite biology and clinical outcomes, but remains challenging, especially with partial sequences, such as the DB...

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Literature Corpus work: a6c5f4d6-26c0-598f-ba95-517fef5c3676
DOI: 10.1101/2025.05.19.654848

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