Article

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

2023-05-12

Abstract excerpt

Protein degradation in eukaryotic cells is mainly carried out by the 26S proteasome, a macromolecular complex not only present in the cytosol and nucleus but also associated with various membranes. How proteasomes are anchored to the membrane and the biological meaning thereof have been largely unknown in higher organisms. Here we show that N-myristoylation of the Rpt2 subunit is a general mechanism for proteasome...

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Literature Corpus work: a69fd01f-38ad-5def-93b5-9ca89c11fd1a
DOI: 10.1101/2023.05.12.540509

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