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Article

Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-modified proteins.

Journal of lipid research - 1 Jul 2006

Lu Jui-Yun, Hofmann Sandra L

Abstract excerpt

Much is now understood concerning the synthesis of prenylated and palmitoylated proteins, but what is known of their metabolic fate? This review details metabolic pathways for the lysosomal degradation of S-fatty acylated and prenylated proteins. Central to these pathways are two lysosomal enzymes, palmitoyl-protein thioesterase (PPT1) and prenylcysteine lyase (PCL). PPT1 is a soluble lipase that cleaves fatty...

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Carbon-Sulfur Lyases
Glycosylphosphatidylinositols
Lipid Metabolism
Lysosomes
Myristic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Prenylation

Protein Processing, Post-Translational

Thiolester Hydrolases

Source

Identifiers

PMID: 16627894
DOI: 10.1194/jlr.R600010-JLR200

Genes

PPT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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