Article

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

2020-09-20

Abstract excerpt

Reversible phosphorylation has emerged as an important mechanism for regulating 26S proteasome function in health and disease. Over 100 phospho-tyrosine (pTyr) sites of the human proteasome have been detected, and yet their function and regulation remain poorly understood. Here we show that the 19S subunit Rpt2 is phosphorylated at Tyr439, a strictly conserved residue within the C-terminal HbYX motif of Rpt2 that...

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Literature Corpus work: 597baaed-5dee-5045-90d6-9b0a33b5607b
DOI: 10.1101/2020.09.20.305532

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