Article

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in <i>Caenorhabditis elegans</i>

2018-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Cilia and extracellular vesicles (EVs) are signaling organelles that play important roles in human health and disease. In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 and polycystin-2 localize to both cilia and EVs, act in the same genetic pathway, and function in a sensory capacity, suggesting ancient conservation. Hence, the nemat...

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Literature Corpus work: 00384878-b0a6-5153-9361-9cc35e3e7458
DOI: 10.1101/376152

Open publication

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