Article

Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes

2020-03-11

Abstract excerpt

<title>Abstract</title> <p>Background T cells expressing a chimeric antigen receptor (CAR) engineered to target CD19 can treat leukemia effectively but also increase the risk of complications such as cytokine release syndrome (CRS) and CAR T cell related encephalopathy (CRES) driven by interleukin-6 (IL-6). Here, we investigated whether IL-6 knockdown in CART-19 cells can reduce IL-6 secretion from monocytes, whi...

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Literature Corpus work: a224206e-ad92-5c76-b112-6f3275eecc18
DOI: 10.21203/rs.3.rs-16656/v1

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