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Identification of positive and negative regulators in the stepwise developmental progression towards infectivity in Trypanosoma brucei

11 Mar 2021

Abstract excerpt

Trypanosoma brucei is a protozoan parasite that causes important human and livestock diseases in sub-Saharan Africa. By overexpressing a single RNA-binding protein, RBP6, in non-infectious procyclics trypanosomes, we previously recapitulated in vitro the events occurring in the tsetse fly vector, namely the development of epimastigotes and infectious, quiescent metacyclic parasites. To identify genes involved in...

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PMID: 33707699
DOI: 10.1038/s41598-021-85225-2

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