Article
Deep mutational scanning reveals the antibody escape and infectivity landscape of SARS-CoV-2 Omicron JN.1 and XEC receptor-binding domains.
Emerging microbes & infections - 1 Dec 2026
Shao Chengwei, Yang Lisa, Xiao Chuyao, Huang Yumei, Wang Xiangxi, Chen Ling, Liu Pan, Chen Si, Wei Mingwei, Jia Siyue, Cui Lunbiao, Ge Yiyue, Xu Ming, Jia Xiaoyan, Li Jingxin
Abstract excerpt
SARS-CoV-2 continuously accumulates mutations in the spike receptor-binding domain (RBD), affecting both viral infectivity and antibody evasion. Systematic characterization of RBD mutations is therefore essential for understanding viral adaptation under immune pressure and predicting evolutionary trajectories. In this study, we employed a two-step, non-replicating pseudovirus deep mutational scanning (DMS)...
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