Article

Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

2019-11-12

Abstract excerpt

Contact repulsion of growing axons is an essential mechanism for spinal nerve patterning. In birds and mammals the embryonic somites generate a linear series of impenetrable barriers, forcing axon growth cones to traverse one half of each somite as they extend towards their body targets. This study shows that protein disulphide isomerase provides a key component of these barriers, mediating contact repulsion at th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6333773-e413-5852-b179-3e30628a59d1
DOI: 10.1101/838771

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of nerve growth and patterning by cell surface protein disulphide isomeraseDOI 10.1101/838771Read

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.Semantic proximity Read

Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeetSemantic proximity Read

Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.Semantic proximity Read

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.Semantic proximity Read

Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.Semantic proximity Read

Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity.Semantic proximity Read

Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension.Semantic proximity Read

Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explantsSemantic proximity Read

A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth PlatesSemantic proximity Read

Dimerization of postsynaptic neuroligin drives synaptic assembly via transsynaptic clustering of neurexin.Semantic proximity Read

Regulated cleavage of a contact-mediated axon repellent.Semantic proximity Read

Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells.Semantic proximity Read