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Article

Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.

Neuron - 20 Dec 2007

Fabrichny Igor P, Leone Philippe, Sulzenbacher Gerlind, Comoletti Davide, Miller Meghan T, Taylor Palmer, Bourne Yves, Marchot Pascale

Abstract excerpt

The neuroligins are postsynaptic cell adhesion proteins whose associations with presynaptic neurexins participate in synaptogenesis. Mutations in the neuroligin and neurexin genes appear to be associated with autism and mental retardation. The crystal structure of a neuroligin reveals features not found in its catalytically active relatives, such as the fully hydrophobic interface forming the functional...

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Source

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Identifiers

PMID: 18093521
DOI: 10.1016/j.neuron.2007.11.013
PMCID: PMC2703725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.PMID 18093521Read ↗

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