Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension.

Experimental neurology - 1 Apr 2008

Hamel Michelle G, Ajmo Joanne M, Leonardo Christopher C, Zuo Fengrong, Sandy John D, Gottschall Paul E

Abstract excerpt

Aggregating proteoglycans (PG) bearing chondroitin sulfate (CS) side chains associate with hyaluronan and various secreted proteins to form a complex of extracellular matrix (ECM) that inhibits neural plasticity in the central nervous system (CNS). Chondroitinase treatment depletes PGs of their CS side chains and enhances neurite extension. Increasing evidence from in vivo models indicates that proteolytic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Analysis of Variance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Newborn

Share to Astrocytes

Share to Dose-Response Relationship, Drug

Share to Enzyme Inhibitors

Share to Neurites

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 18178186
DOI: 10.1016/j.expneurol.2007.11.014
PMCID: PMC2614334

Genes

ADAMTS4
ADAMTS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension.PMID 18178186Read ↗

New Insights into ADAMTS Metalloproteases in the Central Nervous SystemSemantic proximity Read ↗

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.Semantic proximity Read ↗

Neural stem cells at the crossroads: MMPs may tell the waySemantic proximity Read ↗

Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injurySemantic proximity Read ↗

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.Semantic proximity Read ↗

Metalloproteinases in biology and pathology of the nervous systemSemantic proximity Read ↗

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.Semantic proximity Read ↗

Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.Semantic proximity Read ↗

The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.Semantic proximity Read ↗

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).Semantic proximity Read ↗

The TIMPs tango with MMPs and more in the central nervous systemSemantic proximity Read ↗

Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.