Article

PANACEA: a framework to maximise genetic diversity in genome-wide association study meta-analyses

2026-08-10

Abstract excerpt

<h4>ABSTRACT</h4> There have been recent efforts by the human genetics research community to increase the genetic diversity of participants contributing to genome-wide association studies (GWAS) of complex human traits and diseases. The traditional multi-ancestry GWAS approach is to first assign participants to continental ancestry labels based on their genetic similarity to individuals in reference datasets. Anc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a60cb28c-581a-55f5-b85c-82b8eb21cd74
DOI: 10.64898/2026.08.06.26359891

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PANACEA: a framework to maximise genetic diversity in genome-wide association study meta-analysesDOI 10.64898/2026.08.06.26359891Read

Evaluating Multi-Ancestry Genome-Wide Association Methods: Statistical Power, Population Structure, and Practical ImplicationsSemantic proximity Read

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications.Semantic proximity Read

The Impact of Ancestry on Genome-Wide Association Studies.Semantic proximity Read

A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS CatalogSemantic proximity Read

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity Read

Impact of cross-ancestry genetic architecture on GWAS in admixed populationsSemantic proximity Read

Methods for multiancestry genome-wide association study meta-analysis.Semantic proximity Read

Using the UK Biobank as a global reference of worldwide populations: application to measuring ancestry diversity from GWAS summary statistics.Semantic proximity Read

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.Semantic proximity Read

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translationSemantic proximity Read

Impact of cross-ancestry genetic architecture on GWASs in admixed populations.Semantic proximity Read

DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.Semantic proximity Read