Article

Generalizable AI predicts immunotherapy outcomes across cancers and treatments

2025-05-05

Abstract excerpt

Immune checkpoint inhibitors are standard across cancers, yet most patients do not respond and existing biomarkers generalize poorly across tumor types, drugs and clinical settings. We present C ompass , a pan-cancer foundation model that predicts immunotherapy response from bulk tumor transcriptomes using a concept-bottleneck transformer. C ompass encodes gene expression through 44 biologically grounded immune...

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Literature Corpus work: 5e42a3cb-7507-52a1-9246-83090c270984
DOI: 10.1101/2025.05.01.25326820

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