Article

Single-cell foundation models predict durable CAR T response despite imperfect cell annotation

2026-07-31

Abstract excerpt

<title>Abstract</title> <p>CD19-targeted chimeric antigen receptor (CAR) T cell therapy achieves high initial response rates in B-cell acute lymphoblastic leukemia (B-ALL), yet half of patients relapse within one year. Pre-infusion product composition decoded by single-cell RNA sequencing (scRNA-seq) carries information predictive of long-term CAR T persistence, but extracting this information from individual pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 198d2bb3-8071-51de-ae9c-b5d89087c4d5
DOI: 10.21203/rs.3.rs-10412263/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell foundation models predict durable CAR T response despite imperfect cell annotationDOI 10.21203/rs.3.rs-10412263/v1Read

Single-cell foundation models predict durable CAR T response despite imperfect cell annotationSemantic proximity Read

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T TherapySemantic proximity Read

Functional diversification and dynamics of CAR-T cells in patients with B-ALLSemantic proximity Read

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma PatientsSemantic proximity Read

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALLSemantic proximity Read

Single-Cell Analysis Reveals Ide-cel and Cilta-cel Characteristics That Influence EfficacySemantic proximity Read

Single-cell profiling of CAR-T CD19 cell phenotypes and immune system dynamics in pediatric BCP-ALLSemantic proximity Read

Common trajectories of highly effective CD19-specific CAR T cells identified by endogenous T cell receptor lineagesSemantic proximity Read

Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage ModelingSemantic proximity Read

CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignanciesSemantic proximity Read

Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19 positive relapse in patients with ALLSemantic proximity Read

Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologiesSemantic proximity Read