Article

UNC-45 assisted myosin folding depends on a conserved FX <sub>3</sub> HY motif implicated in Freeman Sheldon Syndrome

2022-08-08

Abstract excerpt

<h4>Summary</h4> Myosin motors are critical for diverse motility functions ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub in myosin quality control. We show that UNC-45 forms discrete complexes with folded and unfolded my...

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Literature Corpus work: a6034d50-e0b2-5592-9ab8-6b39b45ff4c9
DOI: 10.1101/2022.08.08.502945

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