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Article

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.

Nature cell biology - 1 Apr 2007

Janiesch Philipp Christoph, Kim Johnny, Mouysset Julien, Barikbin Roja, Lochmüller Hanns, Cassata Giuseppe, Krause Sabine, Hoppe Thorsten

Abstract excerpt

Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assembly and myofibril organization, both in Caenorhabditis elegans and humans. The developmentally...

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PMID: 17369820
DOI: 10.1038/ncb1554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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