Article
X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster.
Structure (London, England : 1993) - 9 Mar 2011
Lee Chi F, Hauenstein Arthur V, Fleming Jonathan K, Gasper William C, Engelke Valerie, Sankaran Banumathi, Bernstein Sanford I, Huxford Tom
Abstract excerpt
UCS proteins, such as UNC-45, influence muscle contraction and other myosin-dependent motile processes. We report the first X-ray crystal structure of a UCS domain-containing protein, the UNC-45 myosin chaperone from Drosophila melanogaster (DmUNC-45). The structure reveals that the central and UCS domains form a contiguous arrangement of 17 consecutive helical layers that arrange themselves into five discrete...
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