Article

A roadblock-and-kill model explains the dynamical response to the DNA-targeting antibiotic ciprofloxacin

2019-10-02

Abstract excerpt

Fluoroquinolones - antibiotics that cause DNA damage by inhibiting DNA topoisomerases - are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone exposure has hardly been investigated, although the SOS response, triggered by DNA damage, is often thought to play a key role. Here we investigate growth inhibition of...

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Literature Corpus work: a5fdf1fd-dc77-58af-a5df-62a02522119c
DOI: 10.1101/791145

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