Article
A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin.
Antimicrobial agents and chemotherapy - 20 Aug 2020
Ojkic Nikola, Lilja Elin, Direito Susana, Dawson Angela, Allen Rosalind J, Waclaw Bartlomiej
Abstract excerpt
Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases, are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone exposure has hardly been investigated, although the SOS response, triggered by DNA damage, is often thought to play a key role. Here, we investigated the growth...
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