Article

Race to survival during antibiotic breakdown determines the minimal surviving population size

2022-08-04

Abstract excerpt

A common strategy used by bacteria to resist antibiotics is enzymatic degradation or modification. Such a collective mechanism also enhances the survival of nearby cells, an effect that increases with the number of bacteria that are present. Collective resistance is of clinical significance, yet a quantitative understanding at the population level is lacking. Here we develop a general theoretical framework of coll...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b98a2cf2-8bd6-548f-9496-46fa4893004e
DOI: 10.1101/2022.08.04.502802

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Race to survival during antibiotic breakdown determines the minimal surviving population sizeDOI 10.1101/2022.08.04.502802Read

Collective antibiotic resistance: mechanisms and implications.Semantic proximity Read

Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells.Semantic proximity Read

Microscale spatial fragmentation promotes bacterial survival under antibioticsSemantic proximity Read

Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity.Semantic proximity Read

Higher levels of antibiotic resistance are less competitive: the hidden ecological cost of no-metabolic cost resistanceSemantic proximity Read

Robust, linear correlations between growth rates and β-lactam–mediated lysis ratesSemantic proximity Read

Dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic toleranceSemantic proximity Read

Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations.Semantic proximity Read

STRESS HISTORY ESTABLISHES A TRANSIENT TOLERANT STATE THAT SHAPES ANTIBIOTIC SURVIVAL UPON RESUSCITATIONSemantic proximity Read

A quantitative approach to easily characterize and predict cell death and escape to β-lactam treatmentsSemantic proximity Read

Antibiotic resistant bacteria survive treatment by doubling while shrinking.Semantic proximity Read

Phenotypic resistant single-cell characteristics under recurring ampicillin antibiotic exposure in Escherichia coli.Semantic proximity Read