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Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain.

Emerging microbes & infections - 1 Dec 2024

Niu Xiao, Li Zhiqiang, Wang Jing, Jian Fanchong, Yu Yuanling, Song Weiliang, Yisimayi Ayijiang, Du Shuo, Zhang Zhiying, Wang Qianran, Wang Jing, An Ran, Wang Yao, Wang Peng, Sun Haiyan, Yu Lingling, Yang Sijie, Xiao Tianhe, Gu Qingqing, Shao Fei, Wang Youchun, Xiao Junyu, Cao Yunlong

Abstract excerpt

A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it is crucial for comprehending the impact of NTD mutations on viral fitness and guiding vaccine design. In this study, we find that most of NTD-targeting antibodies isolated from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39361729
DOI: 10.1080/22221751.2024.2412990
PMCID: PMC11520098

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