Article

CRISPR/Cas9 screening reveals that ASB2 inhibits p53-dependent ferroptosis to mediates Lenvatinib resistance in hepatocellular carcinoma

2023-01-09

Abstract excerpt

<h4>Background: </h4> Lenvatinib is in a first-line therapy for advanced hepatocellular carcinoma (HCC), but its resistance is one of the main obstacles to treatment failure. The molecular mechanism of Lenvatinib resistance has not been well explored. Methods Genome-wide CRISPR/Cas9 knockout screening system was developed and bioinformatic analysis was used to identify key genes associated with Lenvatinib resistan...

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Literature Corpus work: 74fd2c8e-cad5-5845-b75b-4366216d495d
DOI: 10.21203/rs.3.rs-2444654/v1

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