Article

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

2019-09-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> RNA helicase DEAD box protein 5 (DDX5) is downregulated during hepatitis B virus (HBV) replication, and associates with poor prognosis HBV-related hepatocellular carcinoma (HCC). The aim of this study is to determine the mechanism and significance of DDX5 downregulation for HBV-driven HCC. <h4>Approach & Results</h4> We used established cellular models of HBV repli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 013b22d8-dea1-53e7-9cbb-1de587954aec
DOI: 10.1101/765388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular CarcinomaDOI 10.1101/765388Read

Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinomaSemantic proximity Read

DDX5 and DDX17 RNA helicases regulate hepatitis B virus RNA splicingSemantic proximity Read

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancerSemantic proximity Read

HBx Protein Contributes to Liver Carcinogenesis by H3K4me3 Modification Through Stabilizing WD Repeat Domain 5 ProteinSemantic proximity Read

RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA EncapsidationSemantic proximity Read

Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytesSemantic proximity Read

DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwindingSemantic proximity Read

Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses.Semantic proximity Read

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration and Tumor Growth in Zebrafish and MiceSemantic proximity Read

A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesisSemantic proximity Read

SNRPG serves as a novel predictor of prognosis and tumor development for hepatocellular carcinoma by activating Wnt/β-catenin signalingSemantic proximity Read

RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune SignalingSemantic proximity Read