Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1

9 Dec 2024

Abstract excerpt

BACKGROUND: Sorafenib is a commonly used first-line kinase-targeted drug for advanced hepatocellular carcinoma (HCC) patients suffering from limited efficacy. Emerging evidence indicates that sorafenib exerts anti-cancer activity through the induction of ferroptosis in HCC cells, but the underlying mechanism is still unclear. METHODS: The whole transcriptome sequencing and bioinformatics analysis were used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Ferroptosis and cancer prognosis
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39652303
DOI: 10.1007/s13402-024-01017-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1PMID 39652303Read ↗

Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinomaSemantic proximity Read ↗

Role of ferroptosis in hepatocellular carcinoma.Semantic proximity Read ↗

Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinomaSemantic proximity Read ↗

5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosisSemantic proximity Read ↗

Ferroptosis regulator genes are a favorable biomarker for hepatocellular carcinomaSemantic proximity Read ↗

The Expression of Ferroptosis-Related Genes in Hepatocellular Carcinoma and Their Relationships With PrognosisSemantic proximity Read ↗

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinomaSemantic proximity Read ↗

Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR‐3200‐5p/ATF4 AxisSemantic proximity Read ↗

ALOXE3 transcriptionally regulated by activating transcription factor 3 promotes HCC ferroptosis via ERK and JNK signaling pathwaySemantic proximity Read ↗

Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer.Semantic proximity Read ↗

Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinomaSemantic proximity Read ↗

Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.