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The Spectrum of Genetic Risk in Alzheimer Disease

29 Jan 2025

Abstract excerpt

Alzheimer disease (AD), the most common dementing syndrome in the United States, is currently established by the presence of amyloid-β and tau protein biomarkers in the setting of clinical cognitive impairment. These straightforward diagnostic parameters belie an immense complexity of genetic architecture underlying risk and presentation in AD. In this review, we provide a focused overview of the current state of...

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PMID: 39885961
DOI: 10.1212/nxg.0000000000200224

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