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PC1-guided transcriptomic stratification reveals hepatic transcriptional heterogeneity and defines a myeloid-associated 20-gene signature

2026-08-18

Abstract excerpt

Hepatic lipid-associated inflammation contributes to metabolic liver disease and cardiometabolic complications. Treatment-based transcriptomic comparisons can obscure inter-individual heterogeneity when animals exposed to the same experimental condition show divergent molecular responses. In the public hyperlipidemic liver transcriptomic dataset GSE338111, conventional sex-adjusted comparison of Amlexanox versus D...

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Literature Corpus work
a5e28e06-6183-550a-9c07-62f1bfd912f8
DOI
10.64898/2026.08.14.744782
Open publication

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PC1-guided transcriptomic stratification reveals hepatic transcriptional heterogeneity and defines a myeloid-associated 20-gene signatureDOI 10.64898/2026.08.14.744782
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