Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The association between lipid metabolism and coronary artery disease: A systematic Mendelian randomization study combined with transcriptome analysis.

Medicine - 27 Mar 2026

Bure Qi, Sun Wenjin, Wang Lujiao, Zhang Xin, Shuang Lian

Abstract excerpt

Coronary artery disease (CAD), a chronic progressive inflammatory cardiovascular disorder and leading global cause of mortality, imposes a substantial worldwide economic burden. Identifying lipid metabolism-related genes linked to CAD is crucial for deepening our understanding of the disease's pathogenesis and discovering novel therapeutic targets. A total of 700 differentially expressed genes associated with CAD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genome-Wide Association Study

Share to Lipid Metabolism

Share to Machine Learning

Share to Mendelian Randomization Analysis

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41894294
DOI: 10.1097/MD.0000000000047880
PMCID: PMC13034972

Genes

CAD
AGPAT3
HMGCR
MAPKAPK2
SCP2
TNFAIP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association between lipid metabolism and coronary artery disease: A systematic Mendelian randomization study combined with transcriptome analysis.PMID 41894294Read ↗

Transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-related drug targets for cardiometabolic diseases.Semantic proximity Read ↗

Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart diseaseSemantic proximity Read ↗

Identification of lipid metabolism-related biomarkers for diagnosis and molecular classification of atherosclerosisSemantic proximity Read ↗

Genetic effects of inflammatory cytokines on coronary artery disease and myocardial infarction and the mediating roles of lipid traits.Semantic proximity Read ↗

Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis.Semantic proximity Read ↗

Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels.Semantic proximity Read ↗

A stratified study of human blood metabolites and coronary artery diseases-A Mendelian randomization study.Semantic proximity Read ↗

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery diseaseSemantic proximity Read ↗

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read ↗

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular diseaseSemantic proximity Read ↗

Insights Into Causal Effects of Genetically Proxied Lipids and Lipid-Modifying Drug Targets on Cardiometabolic Diseases.Semantic proximity Read ↗

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.