Article

Estrogen receptor β exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity

2019-11-20

Abstract excerpt

Estrogen receptor β (ERβ) was first identified in the rodent prostate and is abundantly expressed in human and rodent prostate epithelium, stroma, immune cells and endothelium of the blood vessels. In the prostates of mice with inactivated ERβ, mutant phenotypes include epithelial hyperplasia and increased expression of androgen receptor (AR)-regulated genes, most of which are also upregulated in prostate cancer (...

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Literature Corpus work: a5d23b8e-ff33-5877-896f-be3ad8c77b08
DOI: 10.1101/850180

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