Article
Androgen receptor signaling in prostate cancer.
Cancer metastasis reviews - 1 Sept 2014
Culig Zoran, Santer Frédéric R
Abstract excerpt
The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary prostate cancer and in metastases. AR regulates multiple cellular events, proliferation, apoptosis, migration, invasion, and differentiation. Its expression in prostate cancer cells is regulated by steroid and peptide hormones. AR downregulation by various compounds which are contained in fruits and vegetables is considered a...
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