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Estrogen Signals through ERβ in Breast Cancer; What We Have Learned since the Discovery of the Receptor

3 May 2024

Abstract excerpt

Estrogen receptor (ER) β (ERβ) is the second ER subtype that mediates the effects of estrogen in target tissues along with ERα that represents a validated biomarker and target for endocrine therapy in breast cancer. ERα was the only known ER subtype until 1996 when the discovery of ERβ opened a new chapter in endocrinology and prompted a thorough reevaluation of the estrogen signaling paradigm. Unlike the...

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PMID: 39175529
DOI: 10.3390/receptors3020010

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