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Article

Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor β Repression

1 Mar 2015

Abstract excerpt

The role of ERβ in prostate cancer is unclear, although loss of ERβ is associated with aggressive disease. Given that mice deficient in ERβ do not develop prostate cancer, we hypothesized that ERβ loss occurs as a consequence of tumorigenesis caused by other oncogenic mechanisms and that its loss is necessary for tumorigenesis. In support of this hypothesis, we found that ERβ is targeted for repression in...

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PMID: 25818291
DOI: 10.1016/j.celrep.2015.02.063

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