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The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression

16 Apr 2024

Abstract excerpt

Just like the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the prostate and is thought to influence prostate cancer (PCa) biology. Yet the incomplete understanding of ERα functions in PCa hinders our ability to fully comprehend its clinical relevance and restricts the repurposing of estrogen-targeted therapies for the treatment of this disease. Using 2 human PCa tissue microarray cohorts,...

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Share to Cancer, Lipids, and Metabolism
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PMID: 38625747
DOI: 10.1172/jci170809

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