Article

From Cardiac Myosin to the Beta Receptor: Autoantibodies Promote a Fibrotic Transcriptome and Reduced Ventricular Recovery in Human Myocarditis

2024-06-23

Abstract excerpt

<h4>Background</h4> Myocarditis leads to dilated cardiomyopathy (DCM) with one-third failing to recover normal ejection fraction (EF50%), and there is a critical need for prognostic biomarkers to assess risk of nonrecovery. Cardiac myosin (CM) autoantibodies (AAbs) cross-reactive with the β−adrenergic receptor (βAR) are associated with myocarditis/DCM, but their potential for prognosis and functional relevance is...

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Literature Corpus work: a5bb9fa4-23cf-5433-852e-dc1709ad0385
DOI: 10.1101/2024.06.19.599804

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