Article
Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis.
Journal of the American Heart Association - 14 Jan 2016
Cordero-Reyes Andrea M, Youker Keith A, Trevino Alejandro R, Celis Rene, Hamilton Dale J, Flores-Arredondo Jose H, Orrego Carlos M, Bhimaraj Arvind, Estep Jerry D, Torre-Amione Guillermo
Abstract excerpt
BACKGROUND: Limited information exists on the role of B-cell-dependent mechanisms in the progression of heart failure (HF). However, in failing human myocardium, there is evidence of deposition of activated complement components as well as anticardiac antibodies. We aimed to determine the contribution of B-cells in HF progression using a nonsurgical mouse model of nonischemic cardiomyopathy (CMP). METHODS AND...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.