Article

Dissecting antibody responses to cardiac receptors in patients with myocardial infarction

2025-11-06

Abstract excerpt

Myocardial infarction (MI) triggers the production of heart-reactive serum antibodies, but their antigen specificities and impact on cardiomyocyte function remain poorly understood. Using single-cell RNA and B cell receptor sequencing (scRNA/BCRseq) on plasmablasts isolated from patients with MI combined with antibody engineering, we identified B cell clones expanded in response to MI, and generated a panel of 17...

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Literature Corpus work: 6bad2254-90ce-5bc3-adc1-54a2c1597345
DOI: 10.1101/2025.11.03.25339371

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