Article
Plant homeodomain fingers form a helping hand for transcription.
Epigenetics - 1 Jan 2011
Fortschegger Klaus, Shiekhattar Ramin
Abstract excerpt
Several recent publications demonstrate a co-activator function for a subgroup of plant homeodomain fingers, which in humans comprises PHF2, PHF8 and KIAA1718. Besides an N-terminal plant homeodomain (PHD) these proteins also harbor an enzymatically active Jumonji-C domain (JmjC). While they have been shown to bind via their PHDs to H3K4me3-bearing nucleosomes at active gene promoters, their JmjC-domains are able...
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