Article

FAM20A deficiency impairs osteogenesis in enamel–renal syndrome

2026-07-06

Abstract excerpt

<title>Abstract</title> <p>Enamel–renal syndrome is a rare inherited disorder caused by mutations in FAM20A, characterized by severe dental defects and ectopic mineralization across multiple tissues. Although FAM20A is essential for mineralized tissue development, how its loss disrupts alveolar bone formation remains unclear. Here, we combined clinical, radiographic and patient-derived cell analyses to define the...

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Literature Corpus work: a9e19fb0-36a3-511e-8088-edc0daa5fb82
DOI: 10.21203/rs.3.rs-9961669/v1

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