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Article

Pharmacological intervention of the FGF-PTH axis as a potential therapeutic for craniofacial ciliopathies.

Disease models & mechanisms - 1 Aug 2022

Bonatto Paese Christian Louis, Chang Ching-Fang, Kristeková Daniela, Brugmann Samantha A

Abstract excerpt

Ciliopathies represent a disease class characterized by a broad range of phenotypes including polycystic kidneys and skeletal anomalies. Ciliopathic skeletal phenotypes are among the most common and most difficult to treat due to a poor understanding of the pathological mechanisms leading to disease. Using an avian model (talpid2) for a human ciliopathy with both kidney and skeletal anomalies (orofaciodigital...

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Identifiers

PMID: 35818799
DOI: 10.1242/dmm.049611
PMCID: PMC9403750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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