Article

Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function

2025-06-17

Abstract excerpt

Mutations in the RNA-binding protein FUS lead to nuclear depletion and cytoplasmic mislocalisation of the protein and cause amyotrophic lateral sclerosis (ALS). Using a novel FUS-ALS mouse model, we found that adult mutant mice develop loss of function transcriptomic alterations, along with aberrant cytoplasmic partitioning associated with translatome deficits. Neuromuscular junction innervation was selectively im...

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Literature Corpus work: 6858135d-facf-5040-ab9e-ee2f3896cecb
DOI: 10.1101/2025.06.16.659513

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